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| Product Name: | BAFF, HUMAN | | Synonyms: | CD257, SOLUBLE (HUMAN);BLYS, SOLUBLE (HUMAN);B-CELL ACTIVATING FACTOR, HUMAN;BAFF, HUMAN;BAFF, HUMAN, RECOMBINANT;HUMAN B CELL ACTIVATING FACTOR;HSBLYS;B-CELL ATTRACTING FACTOR, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![BAFF, HUMAN Structure]() |
| | BAFF, HUMAN Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder | | biological source | human |
| WGK Germany | 3 | | Storage Class | 13 - Non Combustible Solids |
| | BAFF, HUMAN Usage And Synthesis |
| Biological Activity | BAFF, a member of the TNF superfamily of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. Recombinant human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF. | | Description | BAFF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton.
The BAFF is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | BAFF binds to tnfrsf13b/taci and tnfrsf17/bcma. Tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response.
B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays.
Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin. |
| | BAFF, HUMAN Preparation Products And Raw materials |
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