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| | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH Basic information |
| Product Name: | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH | | Synonyms: | (lys-8-psi-ch2nh-lys9)-neurotensin*fragment 8-13;neurotensin, fragment 8-13, [Lys8-psi-(CH2NH)-Lys9];KKPYIL;[LYS8,9]-NEUROTENSIN (8-13);(LYS8,LYS9)-NEUROTENSIN (8-13);LYS-LYS-PRO-TYR-ILE-LEU;L-Leucine, L-lysyl-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-;Lys8,9]-Neurotensin (8-13),KKPYIL | | CAS: | 139026-64-5 | | MF: | C38H64N8O8 | | MW: | 760.96 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 139026-64-5.mol |  |
| | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH Chemical Properties |
| Boiling point | 1109.7±65.0 °C(Predicted) | | density | 1.203±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | form | Solid | | pka | 3.41±0.10(Predicted) | | color | White to off-white | | Sequence | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH |
| | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH Usage And Synthesis |
| Uses | [Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1]. | | References | [1] Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544. DOI:10.1021/acschemneuro.9b00390 |
| | H-Lys-Lys-Pro-Tyr-Ile-Leu-OH Preparation Products And Raw materials |
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