2',5'-DIDEOXYADENOSINE
| 中文名称 | 2',5'-DIDEOXYADENOSINE |
|---|---|
| 中文同义词 | 2',5'-双脱氧腺苷;2',5'-二脱氧腺苷;化合物2',5'-DIDEOXYADENOSINE;(2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇;化合物 2',5'-DIDEOXYADENOSINE;化合物2',5'-DIDEOXYADENOSINE,10 MM DMSO 溶液 |
| 英文名称 | 2',5'-DIDEOXYADENOSINE |
| 英文同义词 | 2',5'-DD-ADO;5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL;(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol;NSC 95943;NSC 95943 2',5'-DIDEOXYADENOSINE;phosphoric acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl [hydroxy(phosphonooxy)phosphoryl] [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] ester;2,5-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem;Adenosine, 2',5'-dideoxy- |
| CAS号 | 6698-26-6 |
| 分子式 | C10H13N5O2 |
| 分子量 | 235.24 |
| EINECS号 | |
| 相关类别 | 化学试剂;Adenylate cyclaseG Proteins and Cyclic Nucleotides;Adenylyl Cyclase Inhibitors;A to;Cyclic Nucleotide Metabolism;Enzyme Inhibitors by Enzyme |
| Mol文件 | 6698-26-6.mol |
| 结构式 |  |
2',5'-DIDEOXYADENOSINE 性质
| 沸点 | 547.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.77±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.06±0.60(Predicted) |
| 颜色 | 白色 |
| InChI | InChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1 |
| InChIKey | FFHPXOJTVQDVMO-DSYKOEDSSA-N |
| SMILES | C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O |
IC50: 3 µM (adenylyl cyclase)
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
| Cell Line: | Primary hippocampal neurons |
| Concentration: | 10 μM |
| Incubation Time: | 30 min |
| Result: | Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). |
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K
+
and Cl
-
sparing effect of Fr•EtOAc in rats.
| Animal Model: | Male Wistar rats (3-4 months old) |
| Dosage: | 0.1 mg/kg |
| Administration: | IP; 15 min pre-treated |
| Result: | Fully inhibited the diuretic, natriuretic and K + and Cl - sparing effect of Fr•EtOAc in rats. |
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 29349990 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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