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| | 2-Amino-5-bromobenzotrifluoride Basic information |
| | 2-Amino-5-bromobenzotrifluoride Chemical Properties |
| Hazard Codes | Xn,Xi,C | | Risk Statements | 20/21/22-36/37/38-34 | | Safety Statements | 26-36-36/37/39-45-27 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | HS Code | 29214300 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Amino-5-bromobenzotrifluoride Usage And Synthesis |
| Chemical Properties | Clear yellow liquid | | Uses | 4-Bromo-2-(trifluoromethyl)aniline has been used in the preparation of 2,5-dibromo-(trifluoromethyl)benzene and 5-bromo-2-iodo-(trifluoromethyl)benzene. | | Uses | 2-Amino-5-bromobenzotrifluoride is a reagent used for the synthesis of α-aminophosphonate which exhibits moderate antitumor activity. | | Synthesis | The general procedure for the synthesis of 2-amino-5-bromobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodo-3(1H)-one and 4-bromoaniline is as follows: in this embodiment, the same reaction and post-processing procedure as in Example 28 is used, wherein the aromatic amine is p-bromoaniline. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyl iodo-3(1H)-one (0.5 mmol, 1.0 eq.), aromatic amine (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were used as a base, and the reaction was carried out for 2 hours at 35°C in DMSO (2 mL). After the reaction was completed, post-treatment was performed according to the method of Example 1. | | References | [1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0232-0236
[3] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771
[4] Patent: CN103553857, 2016, B. Location in patent: Paragraph 0019-0020 |
| | 2-Amino-5-bromobenzotrifluoride Preparation Products And Raw materials |
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