4-BROMOBENZYLSULFONYL CHLORIDE manufacturers
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| | 4-BROMOBENZYLSULFONYL CHLORIDE Basic information |
| Product Name: | 4-BROMOBENZYLSULFONYL CHLORIDE | | Synonyms: | BENZENEMETHANESULFONYL CHLORIDE, 4-BROMO-;4-BROMOBENZYLSULFONY;4-Bromobenzylsulphonyl chloride 97%;4-Bromo-α-toluenesulfonyl chloride, 95%;(4-BROMO-PHENYL)-METHANESULFONYL CHLORIDE;4-BROMOBENZYLSULFONYL CHLORIDE;(4-Bromophenyl)methanesulphonyl chloride;(4-Bromophenyl)methanesulphonyl chloride 97% | | CAS: | 53531-69-4 | | MF: | C7H6BrClO2S | | MW: | 269.54 | | EINECS: | | | Product Categories: | | | Mol File: | 53531-69-4.mol |  |
| | 4-BROMOBENZYLSULFONYL CHLORIDE Chemical Properties |
| Melting point | 117 °C | | Boiling point | 116.5-121.5/ | | density | 1.746±0.06 g/cm3(Predicted) | | storage temp. | -20°C, sealed storage, away from moisture | | form | powder | | color | White | | InChI | 1S/C7H6BrClO2S/c8-7-3-1-6(2-4-7)5-12(9,10)11/h1-4H,5H2 | | InChIKey | ZWVWFWGJZPHCHF-UHFFFAOYSA-N | | SMILES | ClS(=O)(=O)Cc1ccc(Br)cc1 | | CAS DataBase Reference | 53531-69-4 |
| Hazard Codes | C,Xn | | Risk Statements | 22 | | RIDADR | UN3261 | | WGK Germany | WGK 3 | | Hazard Note | Corrosive | | HazardClass | 8 | | HS Code | 2904990090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-BROMOBENZYLSULFONYL CHLORIDE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of p-bromobenzyl sulfonyl chloride from 4-bromo-α-toluene thioacetic acid: N-chlorosuccinimide (NCS, 3.3 g, 24.6 mmol) was added batchwise to a solution of acetonitrile (30 mL) containing 2 M HCl (1.547 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 5 min. Subsequently, a solution of 4-bromophenylmethanesulfonyl chloride (1.5 g, 6.15 mmol) in acetonitrile (3 mL) was added dropwise to the mixture at the same temperature, with the dropwise addition time being controlled at 1 min. After continuing to stir the reaction mixture for 10 minutes, anhydrous sodium sulfate (about 5 g) was added and the solid was removed by filtration. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10/1) to afford p-bromobenzylsulfonyl chloride (1.2 g, 73% yield) as a white solid.1H NMR (300 MHz, CDCl3): δ = 7.62 (d, J = 8.4 Hz, 2H), 7.37 (d, J = 8.4 Hz, 2H), 4.83 (s 2H). | | References | [1] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 01167
[2] Patent: US2014/163024, 2014, A1. Location in patent: Paragraph 0432
[3] Patent: US2014/163110, 2014, A1. Location in patent: Page/Page column 12
[4] Patent: WO2015/177325, 2015, A1. Location in patent: Page/Page column 52; 53 |
| | 4-BROMOBENZYLSULFONYL CHLORIDE Preparation Products And Raw materials |
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