A 61603 hydrobromide manufacturers
- A 61603
-
- $362.00
-
2026-07-15
- CAS:107756-30-9
- Purity:
- Supply Ability: 10g
|
| | A 61603 hydrobromide Basic information |
| Product Name: | A 61603 hydrobromide | | Synonyms: | N-[5-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2-HYDROXY-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE HYDROBROMIDE;N-(5-(4,5-Dihydro-(1H)-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamidehydrobromide;A 61603;A 61603, alpha1A-adrenoceptor agonist;N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfonamide, monohydrobromide;Methanesulfonamide, N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-, hydrobromide (1:1) (ACI);A 61603 hydrobromide | | CAS: | 107756-30-9 | | MF: | C14H20BrN3O3S | | MW: | 390.3 | | EINECS: | | | Product Categories: | | | Mol File: | 107756-30-9.mol |  |
| | A 61603 hydrobromide Chemical Properties |
| storage temp. | Desiccate at +4°C | | solubility | Soluble in H2O | | form | crystalline solid | | color | White to off-white | | Water Solubility | Soluble to 50 mM in water |
| | A 61603 hydrobromide Usage And Synthesis |
| Uses | A 61603 is a selective α1A-adrenergic receptor agonist. | | Biological Activity | Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ . | | IC 50 | α1A-adrenergic receptor | | storage | Desiccate at +4°C | | references | [1]. knepper sm, buckner sa, brune me, et al. a-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1a receptor subtype. j pharmacol exp ther, 1995, 274(1): 97-103.
[2]. meyer md, altenbach rj, hancock aa, et al. synthesis and in vitro characterization of n-[5-(4,5-dihydro-1h-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1a receptor agonist. j med chem, 1996, 39(20): 4116-4119.
[3]. luo dl, gao j, fan ll, et al. receptor subtype involved in alpha 1-adrenergic receptor-mediated ca2+ signaling in cardiomyocytes. acta pharmacol sin, 2007, 28(7): 968-974.
[4]. martínez-salas sg1, campos-peralta jm, pares-hipolito j, et al. alpha1a-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. auton autacoid pharmacol, 2007, 27(3): 137-142. |
| | A 61603 hydrobromide Preparation Products And Raw materials |
|