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| | 4-(Trifluoromethoxy)benzaldehyde Basic information |
| | 4-(Trifluoromethoxy)benzaldehyde Chemical Properties |
| Boiling point | 93 °C27 mm Hg(lit.) | | density | 1.331 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.458(lit.) | | Fp | 159 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Liquid | | Specific Gravity | 1.331 | | color | Clear colorless to pale yellow-green | | Sensitive | Air Sensitive | | BRN | 1949135 | | InChI | InChI=1S/C8H5F3O2/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-5H | | InChIKey | XQNVDQZWOBPLQZ-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(OC(F)(F)F)C=C1 | | CAS DataBase Reference | 659-28-9(CAS DataBase Reference) | | NIST Chemistry Reference | Benzaldehyde, 4-(trifluoromethoxy)-(659-28-9) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-36/38-22 | | Safety Statements | 26-36/37/39-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29130000 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-(Trifluoromethoxy)benzaldehyde Usage And Synthesis |
| Chemical Properties | clear colorless to pale yellow-green liquid | | Uses | 4-(Trifluoromethoxy)benzaldehyde is suitable for use in the synthesis of (E)-4-(trifluoromethoxy)benzaldehyde thiosemicarbazone. It may be used in the synthesis of:
- new azo dyes containing of 5(4H)-oxazolone ring
- 2-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole
- (E)-2-[4-(trifluoromethoxy)benzylidene]indan-1-one.
| | General Description | 4-(Trifluoromethoxy)benzaldehyde (p-(trifluoromethoxy)benzaldehyde) is an aromatic aldehyde. It participates in the synthesis of 4,5-dihydro-4-(4-trifluoromethoxyphenyl)pyrrolo[1,2-a]quinoxaline. | | Synthesis | In a flask with a reflux condenser and an inlet tube, 3.62 g of 4-trifluoromethoxybromobenzene, 0.21 g of bis(triphenylphosphine)palladium dichloride, and 1.53 g of sodium formate were added with 15 ml of
DMF were mixed, stirred and heated to 110 C under the condition that CO was passed. After completion of the reaction (GC), the reaction mixture was cooled to 21 C and separated from the catalyst by silica gel filtration. .
The crude product obtained contained 91% p-trifluoromethoxybenzaldehyde and 7% 4-trifluoromethoxybenzyl alcohol (percentages based on area ratio in GC). |
| | 4-(Trifluoromethoxy)benzaldehyde Preparation Products And Raw materials |
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