OSAJIN
| 中文名称 | OSAJIN |
|---|---|
| 中文同义词 | 奥沙京;化合物 Osajin |
| 英文名称 | OSAJIN |
| 英文同义词 | OSAJIN;5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one;5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one;OSAJIN(RG);5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)-4H,8H-pyrano[2,3-f]chromen-4-one;4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one,5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-buten-1-yl)-;NSC 21565;CID 95168 |
| CAS号 | 482-53-1 |
| 分子式 | C25H24O5 |
| 分子量 | 404.46 |
| EINECS号 | |
| 相关类别 | 标准品;植物提取物;标准品 -对照药材;黄酮;对照品 |
| Mol文件 | 482-53-1.mol |
| 结构式 |  |
OSAJIN 性质
| 熔点 | 189° (uncorr), 193° (corr) |
|---|---|
| 沸点 | 632.3±55.0 °C(Predicted) |
| 密度 | 1.258±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.00±0.40(Predicted) |
| 颜色 | 粘黄色 |
| 主要应用 | metabolomics vitamins, nutraceuticals, and natural products |
| 化妆品成分功效 | ANTIOXIDANT |
| InChI | 1S/C25H24O5/c1-14(2)5-10-17-21(27)20-22(28)19(15-6-8-16(26)9-7-15)13-29-24(20)18-11-12-25(3,4)30-23(17)18/h5-9,11-13,26-27H,10H2,1-4H3 |
| InChIKey | DCTLJGWMHPGCOS-UHFFFAOYSA-N |
| SMILES | C\C(C)=C\Cc1c(O)c2C(=O)C(=COc2c3C=CC(C)(C)Oc13)c4ccc(O)cc4 |
Apoptosis
Osajin significantly decreases the viability of human NPC cells (TW076, CG1 and TW04 cells) in a dose-dependent manner. Osajin induces apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress. Osajin exhibits growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells.
Osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemia reperfusion. This is confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-N3125 | Osajin | 482-53-1 | 1 mg | 3100元 |