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| | EXENDIN-4 (3-39) Basic information |
| Product Name: | EXENDIN-4 (3-39) | | Synonyms: | M.W. 3992.42 C176H272N46O58S;GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2;EXENDIN-4 (3-39);EXENDIN (3-39);H-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;EGTFTSDLSK QMEEEAVRLF IEWLKNGGPS SGAPPPS -CONH2 | | CAS: | 196109-31-6 | | MF: | C176H272N46O58S | | MW: | 3992.38128 | | EINECS: | | | Product Categories: | Glucagon receptor and related;peptide | | Mol File: | 196109-31-6.mol |  |
| | EXENDIN-4 (3-39) Chemical Properties |
| storage temp. | -15°C | | Sequence | H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 | | InChIKey | ZCYIPGKMSDDSFW-TYVQEZQOSA-N |
| | EXENDIN-4 (3-39) Usage And Synthesis |
| Uses | Exendin-4 (3-39) is a peptide. Exendin-4 (3-39) is a truncated form of Exendin-4 (HY-13443) that lacks the first two amino acids. Exendin-4 is a potent Glucagon-like peptide-1 receptor (GLP-1r) agonist. Exendin-4 (3-39) and Exendin-4 can be used for the research of diabetic and hypothalamic-pituitary-adrenal (HPA) axis[1][2]. | | in vivo | GLP-1 (i.p.; 5 μg/kg) increases circulating corticosterone and aldosterone levels[2]. | Animal Model: | Rats[2] | | Dosage: | 5 μg/kg | | Administration: | Intraperitoneal injections | | Result: | Increased circulating corticosterone levels in a time-dependent manner both in conscious and anaesthetized rats and also increased aldosterone levels. |
| | References | [1] David Parkes, et al. Pharmacokinetic actions of exendin-4 in the rat: Comparison with glucagon-like peptide-1. (2001), 53(4), 260–267.
[2] Affiliations, et al. GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. Endocrinology. 2010 Jun;151(6):2629-40. DOI:10.1210/en.2009-0915 |
| | EXENDIN-4 (3-39) Preparation Products And Raw materials |
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