(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
| 中文名称 | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE |
|---|---|
| 中文同义词 | (5-苯基-2-脲基)噻吩-3-甲酰胺;(5-苯基-2-脲啶)噻吩-3-羧酰胺;IKK2抑制剂VI |
| 英文名称 | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE |
| 英文同义词 | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE;IKK-2 INHIBITOR VI;2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide;2-(carbamoylamino)-5-phenylthiophene-3-carboxamide;3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide;IKK2 Inhibitor VI,IKK-2 Inhibitor VI;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV |
| CAS号 | 354811-10-2 |
| 分子式 | C12H11N3O2S |
| 分子量 | 261.3 |
| EINECS号 | |
| 相关类别 | Aromatics Compounds;Aromatics;Inhibitors;Sulfur & Selenium Compounds;An ureido-thiophenecarboxamide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of IKK-2 (IC50 = 13 nM). |
| Mol文件 | Mol File |
| 结构式 |  |
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE 性质
| 熔点 | >210°C (dec.) |
|---|---|
| 沸点 | 445.6±45.0 °C(Predicted) |
| 密度 | 1.426±0.06 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO、甲醇（少许） |
| 酸度系数(pKa) | 14.00±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅米色至浅棕色 |
IKK2-IN-4 (compound 4) 是一种有效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 可抑制 LPS 诱导的 PBMC 中 TNFα 的产生。