Lp-PLA2-IN-2

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Lp-PLA2-IN-2 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354;
Email: support@targetmol.com

Lp-PLA2-IN-2 manufacturers

  • Lp-PLA2-IN-2
  • Lp-PLA2-IN-2 pictures
  • $2120.00
  • 2026-05-11
  • CAS:2071636-15-0
  • Purity:
  • Supply Ability: 10g
  • Lp-PLA2-IN-2
  • Lp-PLA2-IN-2 pictures
  • $2120.00
  • 2025-08-22
  • CAS:2071636-15-0
  • Purity:
  • Supply Ability: 10g
Lp-PLA2-IN-2 Basic information
Product Name:Lp-PLA2-IN-2
Synonyms:Lp-PLA2-IN-2;LpPLA2IN2,Lp-PLA-2-IN-2,Lp PLA2 IN 2;Benzonitrile, 2-fluoro-5-[2-[(4S)-2-oxo-4-(tetrahydro-4-methyl-1,1-dioxido-2H-thiopyran-4-yl)-1-pyrrolidinyl]ethoxy]-
CAS:2071636-15-0
MF:C19H23FN2O4S
MW:394.46
EINECS:
Product Categories:
Mol File:2071636-15-0.mol
Lp-PLA2-IN-2 Structure
Lp-PLA2-IN-2 Chemical Properties
Boiling point 637.6±55.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
pka-0.95±0.40(Predicted)
Safety Information
MSDS Information
Lp-PLA2-IN-2 Usage And Synthesis
UsesLp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].
in vivo

Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively[1].

Animal Model:Male Han Wistar rats (250-300 g)[1]
Dosage:1 mg/kg
Administration:i.v. (Pharmacokinetic Analysis)
Result:The Cl, Vss and t1/2 values were 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.
IC 50Lp-PLA2: 120 nM (IC50)
References[1] Woolford AJ, et al. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J Med Chem. 2016 Dec 8;59(23):10738-10749. DOI:10.1021/acs.jmedchem.6b01427
Lp-PLA2-IN-2 Preparation Products And Raw materials
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