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| | Propargyl-NH-PEG3-C2-NHS ester Basic information |
| | Propargyl-NH-PEG3-C2-NHS ester Chemical Properties |
| Boiling point | 476.1±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | pka | 7.07±0.10(Predicted) |
| | Propargyl-NH-PEG3-C2-NHS ester Usage And Synthesis |
| Uses | Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-NH-PEG3-C2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | Non-cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Propargyl-NH-PEG3-C2-NHS ester Preparation Products And Raw materials |
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