Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate

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Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate manufacturers

  • Lipid 5
  • Lipid 5 pictures
  • $697.00
  • 2026-08-05
  • CAS:2089251-33-0
  • Purity:
  • Supply Ability: 10g
  • Lipid 5
  • Lipid 5 pictures
  • 2026-07-24
  • CAS:
  • Min. Order: 1g
  • Purity: 98%
  • Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Basic information
Product Name:Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate
Synonyms:Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate;nonyl 8-[2-hydroxyethyl-[8-(1-octylnonoxy)-8-oxo-octyl]amino]octanoate;1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate;Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester;Lipid 5 (SM-86);Lipid 5
CAS:2089251-33-0
MF:C44H87NO5
MW:710.17
EINECS:
Product Categories:
Mol File:2089251-33-0.mol
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Structure
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Chemical Properties
Boiling point 725.8±50.0 °C(Predicted)
density 0.925±0.06 g/cm3(Predicted)
solubility Soluble in Ethanol, DMSO, DMF
form Liquid
pka14.67±0.10(Predicted)
color Colorless to light yellow
InChIKeyABCVHPIKBGRCJA-UHFFFAOYSA-N
SMILESC(OC(CCCCCCCC)CCCCCCCC)(=O)CCCCCCCN(CCO)CCCCCCCC(OCCCCCCCCC)=O
Safety Information
MSDS Information
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Usage And Synthesis
Description7-[(2-Hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]heptyl 2-octyldecanoate, analog of ALC-0315, is a ionizable, physiological pH cationic synthetic lipid that is used with other lipids to form lipid nanoparticles(LNP) for drug delivery.
UsesLipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects[1].
in vivo

Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].

References[1] Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519. DOI:10.1016/j.ymthe.2018.03.010
Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate Preparation Products And Raw materials
Tag:Heptadecan-9-yl 8-((2-hydroxyethyl)(8-nonyloxy)-8-oxooctyl)amino)octanoate(2089251-33-0) Related Product Information
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