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| | Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Basic information |
| | Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble,DMSO: Soluble,Methanol: Soluble | | form | A solid |
| | Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Usage And Synthesis |
| Uses | Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. | | Biological Activity | Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine .1 It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8. | | IC 50 | Plasmodium | | References | 1.Charlier, B., Pingeon, M., Dal Piaz, F., et al.Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole bloodBiomed. Chromatogr.32(8)e4258(2018) |
| | Hydroxychloroquine Sulfate EP Impurity C-d4 (Desethyl Hydroxy Chloroquine-d4) Preparation Products And Raw materials |
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