1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]-

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1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Suppliers list
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1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- manufacturers

  • Eclitasertib
  • Eclitasertib pictures
  • $108.00
  • 2026-07-27
  • CAS:2125450-76-0
  • Purity: 99.85%
  • Supply Ability: 10g
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Basic information
Product Name:1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]-
Synonyms:1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]-;SAR-443122;SAR-443122,RIPK,Receptor-interacting protein kinases,SAR443122,DNL 758,DNL758,Eclitasertib,Inhibitor,DNL-758,inhibit,RIP kinase,SAR 443122;(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide;Eclitasertib, 10 mM in DMSO;DNL-758;Eclitasertib，5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazepin-3-yl]-2H-1,2,4-triazole-3-carboxamide;Eclitasertib
CAS:2125450-76-0
MF:C19H18N6O3
MW:378.38
EINECS:
Product Categories:
Mol File:2125450-76-0.mol
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Structure
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Chemical Properties
density 1.44±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (330.36 mM; Need ultrasonic)
form Solid
pka8.74±0.40(Predicted)
color White to light yellow
Safety Information
MSDS Information
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Usage And Synthesis
UsesEclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of 0.0375 μΜ[1].
in vivo

Eclitasertib (po, single dose) inhibits TNF-alpha induced hypothermia in mouse models[2].

Animal Model:mouse TNF-alpha induced hypothermia models[2]
Dosage:
Administration:po, single dose
Result:Ameliorated TNF-alpha induced hypothermia.
IC 50RIPK1
References[1] Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.
[2] Darwish I, et al., Rip1k inhibitors. WO2021203011
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- Preparation Products And Raw materials
Tag:1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]-(2125450-76-0) Related Product Information
1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxopyrido[3,2-b][1,4]oxazepin-3-yl]- GSK2982772 1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7-(2-cyclopropylethynyl)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-(phenylmethyl)- 5-Pyrimidinecarboxamide, 2-[(3S)-3-amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]- 1,6-Naphthyridin-2(1H)-one, 3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino] NA