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| | 1,2-BENZENEDIAMINE, 4-IODO- Basic information |
| Product Name: | 1,2-BENZENEDIAMINE, 4-IODO- | | Synonyms: | 4-iodo-1,2-phenylenediaMine;2-Amino-4-iodoaniline;2-Amino-4-iodophenylamine;4-Iodo-1,2-diaminobenzene;1,2-Diamino-4-iodobenzene, 4-Iodophenylene-1,2-diamine;4-Iodobenzene-1,2-diamine 97%;1,2-DiaMino-4-iodobenzene[3,4-DiaMinoiodobenzene];4-Iodo-1,2-phenylenediamine97% | | CAS: | 21304-38-1 | | MF: | C6H7IN2 | | MW: | 234.04 | | EINECS: | | | Product Categories: | | | Mol File: | 21304-38-1.mol |  |
| | 1,2-BENZENEDIAMINE, 4-IODO- Chemical Properties |
| Melting point | 73-77℃ | | Boiling point | 339.0±32.0 °C(Predicted) | | density | 2.016 | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | form | Solid | | pka | 3.37±0.10(Predicted) | | Appearance | Light brown to brown Solid | | Water Solubility | Slightly soluble in water. | | Sensitive | Light Sensitive | | InChI | InChI=1S/C6H7IN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2 | | InChIKey | FUOSRKZBOIVBOS-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(I)C=C1N | | CAS DataBase Reference | 21304-38-1 |
| HazardClass | 6.1 | | HS Code | 2921599090 |
| | 1,2-BENZENEDIAMINE, 4-IODO- Usage And Synthesis |
| Uses | It is employed in the synthesis of N-(Benzimidazol-2-ylmethyl)iminodiacetic acids. | | Synthesis | Using 4-iodo-2-nitroaniline as starting material, the reduction reaction was carried out by adding 5 equivalents of tin dichloride dihydrate to an ethanol solution and reacting at 75°C for 2 hours. Upon completion of the reaction, 4-iodo-1,2-benzenediamine was obtained in 92% yield and the product was a light red solid. | | References | [1] Patent: WO2010/43711, 2010, A1. Location in patent: Page/Page column 56
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6714 - 6723
[3] Patent: US2012/46307, 2012, A1. Location in patent: Page/Page column 27
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2016/79108, 2016, A. Location in patent: Paragraph 0051 |
| | 1,2-BENZENEDIAMINE, 4-IODO- Preparation Products And Raw materials |
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