Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]-

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Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- Basic information
Product Name:Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]-
Synonyms:Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]-
CAS:169521-68-0
MF:C33H50N4O8
MW:630.78
EINECS:
Product Categories:
Mol File:169521-68-0.mol
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- Structure
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- Chemical Properties
Boiling point 819.7±65.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
pka8.57±0.70(Predicted)
Safety Information
MSDS Information
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- Usage And Synthesis
Uses17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities[1][2].
References[1] Jurczyszyn A, et al. Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. J Cancer. 2014;5(6):480-490. Published 2014 May 31. DOI:10.7150/jca.8731
[2] Tian ZQ, et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004;12(20):5317-5329. DOI:10.1016/j.bmc.2004.07.053
Geldanamycin, 17-demethoxy-17-[[3-(dimethylamino)propyl]amino]- Preparation Products And Raw materials
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