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| | Ac-WEHD-AFC (trifluoroacetate salt) Basic information |
| | Ac-WEHD-AFC (trifluoroacetate salt) Chemical Properties |
| solubility | DMSO: 10 mg/ml Water: 1 mg/ml |
| | Ac-WEHD-AFC (trifluoroacetate salt) Usage And Synthesis |
| Description | Ac-WEHD-AFC is a fluorogenic substrate that can be cleaved by group I caspases (caspase-1, -4, and -5).1 Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.WARNING This product is not for human or veterinary use. | | References | [1] KYEWHAN PARK . Expression and characterization of constitutively active human caspase-14[J]. Biochemical and biophysical research communications, 2006, 347 4: Pages 941-948. DOI: 10.1016/j.bbrc.2006.06.156 [2] MARIA BURKOVETSKAYA. Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis[J]. Journal of Neurochemistry, 2018, 148 5: 652-668. DOI: 10.1111/jnc.14480 |
| | Ac-WEHD-AFC (trifluoroacetate salt) Preparation Products And Raw materials |
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