Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Basic information
Product Name:Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)
Synonyms:Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)
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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Structure
Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Usage And Synthesis
DescriptionAngiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . It inhibits renin release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine (Item Nos. 17205 | 18619; EC50 = 0.28 μM). In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II. It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.
References[1] L.M. GUETHE . Angiotensin (5–8) modulates nociception at the rat periaqueductal gray via the NO–sGC pathway and an endogenous opioid[J]. Neuroscience, 2013, 231: Pages 315-327. DOI: 10.1016/j.neuroscience.2012.11.048
[2] A J NAFTILAN  S O. Inhibition of renin release from rat kidney slices by the angiotensins.[J]. American Journal of Physiology, 1978, 235 1: F62-8. DOI: 10.1152/ajprenal.1978.235.1.f62
[3] KARINA GENARO . Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in rats[J]. Behavioural Brain Research, 2013, 256: Pages 537-544. DOI: 10.1016/j.bbr.2013.09.023
Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt) Preparation Products And Raw materials
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