Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)

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Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt) Basic information
Product Name:Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)
Synonyms:Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)
CAS:
MF:C42H55F3N8O10
MW:888.9289096
EINECS:
Product Categories:
Mol File:Mol File
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt) Structure
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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MSDS Information
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt) Usage And Synthesis
DescriptionAngiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . It selectively binds to the angiotensin 2 (AT2) over AT1 receptors (IC50s = 48.6 and >1,000 nM, respectively, in HEK293 cells expressing rat receptors). It also binds to AT4 receptors in bovine aortic endothelial cell membranes (IC50 = 1.6 nM). Angiotensin II (3-8) induces a positive chronotropic effect in isolated rat right atria (EC50 = 4.68 μM) and increases mean arterial pressure (MAP) in vivo in rats when administrated intracerebroventricularly at a dose of 1 pmol. It also increases latency to withdrawal in a tail-flick test in rats when administered by microinjection into the ventrolateral periaqueductal gray (vlPAG).
References[1] SANJA BOSNYAK. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.[J]. Clinical science, 2011, 121 7: 297-303. DOI: 10.1042/cs20110036
[2] SYLVIE G. BERNIER. Characterization of AT4 Receptor from Bovine Aortic Endothelium with Photosensitive Analogues of Angiotensin IV[J]. Biochemistry Biochemistry, 1998, 37 12: 4280-4287. DOI: 10.1021/bi972863j
[3] Q. LI. Direct positive chronotropic effects of angiotensin II and angiotensin III in pithed rats and in rat isolated atria[J]. British Journal of Pharmacology, 1996, 118 7: 1653-1658. DOI: 10.1111/j.1476-5381.1996.tb15588.x
[4] J W WRIGHT. Structure-function analyses of brain angiotensin control of pressor action in rats.[J]. American Journal of Physiology, 1989, 257 6 Pt 2: R1551-7. DOI: 10.1152/ajpregu.1989.257.6.r1551
[5] L.M. GUETHE . Angiotensin (5–8) modulates nociception at the rat periaqueductal gray via the NO–sGC pathway and an endogenous opioid[J]. Neuroscience, 2013, 231: Pages 315-327. DOI: 10.1016/j.neuroscience.2012.11.048
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt) Preparation Products And Raw materials
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