bromchlorenone manufacturers
- bromchlorenone
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- $1.00 / 1KG
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2020-02-05
- CAS:5579-85-1
- Min. Order: 1KG
- Purity: 98%-99.9%HPLC
- Supply Ability: 100KG
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| | bromchlorenone Basic information |
| Product Name: | bromchlorenone | | Synonyms: | bromchlorenone;BROMOCHLORENONE;6-Bromo-5-chloro-3H-1,3-benzoxazol-2-one;6-Bromo-5-chlorobenzoxazol-2(3H)-one;NSC-24970;6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one;6-Bromo-5-chlorobenzo[d]oxazol-2(3H);6-Bromo-5-chloro-3H-benzooxazol-2-one | | CAS: | 5579-85-1 | | MF: | C7H3BrClNO2 | | MW: | 248.46 | | EINECS: | 226-967-0 | | Product Categories: | | | Mol File: | 5579-85-1.mol |  |
| | bromchlorenone Chemical Properties |
| Melting point | 204.5°C | | density | 1.8508 (rough estimate) | | refractive index | 1.6110 (estimate) |
| | bromchlorenone Usage And Synthesis |
| Uses | Anti-infective, topical. | | Synthesis | 2-Amino-5-bromo-4-chlorophenol (Intermediate 7, 8.4 g, 37.8 mmol) and N,N'-carbonyldiimidazole (12.2 g, 75.6 mmol) were used as raw materials and reacted in THF (250 mL) for 3 hours at 80 °C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography (200-400 mesh, 100 g) with petroleum ether/ethyl acetate as eluent (gradient from 9:1 to 5:1) to afford 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one as an orange solid (7.7 g, 82% yield).LCMS (Method A): retention time 1.49 min, molecular ion peak m/z 248 /250 [M+H]+. | | References | [1] Patent: WO2015/91647, 2015, A1. Location in patent: Page/Page column 42 |
| | bromchlorenone Preparation Products And Raw materials |
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