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aistrifarma
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| Products Intro: |
Product Name:Triclofos sodium
CAS:7246-20-0
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| | sodium 2,2,2-trichloroethyl hydrogen phosphate Basic information |
| Product Name: | sodium 2,2,2-trichloroethyl hydrogen phosphate | | Synonyms: | sodium 2,2,2-trichloroethyl hydrogen phosphate;TriclofosSodium;Trichloryl;Tricloryl;Phosphoric acid hydrogen (2,2,2-trichloroethyl)=sodium ester salt;Phosphoric acid sodium(2,2,2-trichloroethyl) ester salt;Sch 10159;Trichlorethyl sodium phosphate | | CAS: | 7246-20-0 | | MF: | C2H3Cl3NaO4P | | MW: | 251.365351 | | EINECS: | 230-652-3 | | Product Categories: | | | Mol File: | 7246-20-0.mol |  |
| | sodium 2,2,2-trichloroethyl hydrogen phosphate Chemical Properties |
| solubility | Freely soluble in water; slightly soluble in ethanol (96%); practically insoluble in ether. | | CAS DataBase Reference | 7246-20-0 |
| Toxicity | LD50 orally in mice: 1.4 g/kg (Hems) |
| | sodium 2,2,2-trichloroethyl hydrogen phosphate Usage And Synthesis |
| Chemical Properties | A white or almost white powder; hygroscopic. | | Originator | Triclos,Merrell National,US,1972 | | Uses | Sedative-hypnotic. | | Manufacturing Process | Trichloroethanol (500 grams) and phosphorus oxychloride (510 grams) were
added to dry diethyl ether (3.5 liters) and stirred at 10°C with ice/water
cooling. Dry pyridine (270 ml) was added dropwise over 1 hour, maintaining
the temperature below 25°C. The resulting suspension was stirred for a
further 1 hour and then stood at 0°C overnight. The pyridine hydrochloride
was removed by filtration and washed with diethyl ether (2 x 300 ml) and
dried in vacuo over P2O5 to give 380 grams.
The ether filtrate and washings were evaporated at room temperature under
reduced pressure to give a clear liquid residue (801 grams). This residue was
distilled under high vacuum to give trichloroethyl phosphorodichloridate (556
grams, 62.4% of theory), boiling point 75°C/0.8 mm.
The phosphorodichloridate was hydrolyzed by adding to a stirred solution of
sodium carbonate (253 grams) in water (2.9 liters). After 1 hour the solution
was cooled and acidified with a solution of concentrated sulfuric acid (30 ml)
in water (150 ml) and then extracted with a mixture of tetrahydrofuran and
chloroform (2.3/1; 3 x 1 liter). The tetrahydrofuran/chloroform liquors were
bulked and evaporated to dryness to give a light brown oil. This was dissolved
in water (1 liter) and titrated with 2 N sodium hydroxide solution to a pH of
4.05 (volume required 930 ml). The aqueous solution was clarified by filtration
through kieselguhr and then evaporated under reduced pressure to a syrup
(737 grams).
Hot acetone (4.5 liters) was added to this syrup and the clear solution stood
at room temperature for 2 hours and then at 0°C overnight. The white
crystalline solid was filtered off, washed with acetone (2 x 400 ml) and dried
at 60°C in vacuo to give sodium trichloroethyl hydrogen phosphate (414
grams, 49.3% of theory from trichloroethanol). | | Brand name | Triclos (Sanofi Aventis). | | Therapeutic Function | Sedative, Hypnotic |
| | sodium 2,2,2-trichloroethyl hydrogen phosphate Preparation Products And Raw materials |
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