| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
|
| Tel: |
0571-87213919 15967184799 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:DBCO-PEG4-Val-Cit-PAB-MMAF
CAS:2244602-23-9
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Nanchang Tianzhen Biotechnology Co., Ltd
|
| Tel: |
13758194781 13173652190 |
| Email: |
522013271@qq.com |
| Products Intro: |
Product Name:DBCO-PEG4-Val-Cit-PAB-MMAF
CAS:2244602-23-9
Purity:98% HPLC Package:5mg，100mg,1g
|
| Company Name: |
YantaiBio
|
| Tel: |
13758194781; 13758194781 |
| Email: |
764619768@qq.com |
| Products Intro: |
Product Name:DBCO-PEG4-Val-Cit-PAB-MMAF
CAS:2244602-23-9
Purity:98% HPLC Package:5mg; 100mg; 1g
|
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| | DBCO-PEG4-Val-Cit-PAB-MMAF Basic information |
| | DBCO-PEG4-Val-Cit-PAB-MMAF Chemical Properties |
| Boiling point | 1577.6±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | solubility | DMSO : 250 mg/mL (149.52 mM; Need ultrasonic) | | form | Solid | | pka | 3.56±0.10(Predicted) | | color | White to off-white |
| | DBCO-PEG4-Val-Cit-PAB-MMAF Usage And Synthesis |
| Uses | DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | Auristatin | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | DBCO-PEG4-Val-Cit-PAB-MMAF Preparation Products And Raw materials |
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