1-phenethylpiperidin-4-ol

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1-phenethylpiperidin-4-ol Basic information
Product Name:1-phenethylpiperidin-4-ol
Synonyms:1-phenethylpiperidin-4-ol;N-(2-Phenylethyl)-4-hydroxypiperidine;1-Phenethyl-4-piperidinol;1-(2-Phenylethyl)piperidin-4-ol;1-(2-Phenylethyl)piperidine-4-ol;4-Hydroxy-1-(2-phenylethyl)piperidine;4-Piperidinol,1-(2-phenylethyl)-;1-(2-Phenylethyl)-4-piperidinol
CAS:3518-76-1
MF:C13H19NO
MW:205.3
EINECS:222-527-7
Product Categories:
Mol File:3518-76-1.mol
1-phenethylpiperidin-4-ol Structure
1-phenethylpiperidin-4-ol Chemical Properties
Melting point 95.5-98.5℃
Boiling point 341.9±22.0 °C(Predicted)
density 1.064±0.06 g/cm3(Predicted)
solubility Acetonitrile: Slightly soluble
Chloroform: Soluble
Water: Slightly soluble
pka14.87±0.20(Predicted)
Safety Information
HS Code 2933399990
MSDS Information
1-phenethylpiperidin-4-ol Usage And Synthesis
Uses1-Phenethyl-4-piperidinol it is used in preparation of 1-Pyrrolidinyl Indane derivatives as Histamine H3 receptor antagonists useful in treatment of diseases.
References[1] SHANAZ M. TEJANI-BUTT . N-Substituted derivatives of 4-piperidinyl benzilate: Affinities for brain muscarinic acetylcholine receptors[J]. Life sciences, 1990, 47 10: Pages 841-848. DOI: 10.1016/0024-3205(90)90596-j
[2] O. PREZZAVENTO*. Design and Synthesis of New Bifunctional Sigma-1 Selective Ligands with Antioxidant Activity[J]. Journal of Medicinal Chemistry, 2013, 56 6: 2447-2455. DOI: 10.1021/jm3017893
[3] SHIMPEI WATANABE. In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.[J]. AAPS Journal, 2017, 19 4: 1102-1122. DOI: 10.1208/s12248-017-0070-z
1-phenethylpiperidin-4-ol Preparation Products And Raw materials
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