4-(ethylamino)piperidine-4-carboxamide manufacturers
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| | 4-(ethylamino)piperidine-4-carboxamide Basic information |
| Product Name: | 4-(ethylamino)piperidine-4-carboxamide | | Synonyms: | 4-(ethylamino)piperidine-4-carboxamide;4-(Ethylamino)-4-piperidinecarboxamide;Einecs 282-134-1;4-PiperidinecarboxaMide,4-(ethylaMino)-;4-Ethylamino-piperidine-4-carboxylic acid amide;NSC 80661 | | CAS: | 84100-54-9 | | MF: | C8H17N3O | | MW: | 171.24 | | EINECS: | 282-134-1 | | Product Categories: | | | Mol File: | 84100-54-9.mol |  |
| | 4-(ethylamino)piperidine-4-carboxamide Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| | 4-(ethylamino)piperidine-4-carboxamide Usage And Synthesis |
| Synthesis | GENERAL STEPS: 1-benzyl-4-(ethylamino)piperidine-4-carboxamide (7.39 g, 28.3 mmol) was dissolved in methanol (100 mL) and 20% Pd(OH)2/C (50% water wetted, 1.48 g) was added. The mixture was placed in a Parr shaker and hydrogenated at 50 psi hydrogen pressure overnight at room temperature. Upon completion of the reaction, the mixture was filtered through a Celite pad and the filtrate was concentrated to give the colorless solid product 4-(ethylamino)-4-piperidinecarboxamide (4.84 g, quantitative yield). Product characterization data: APCI MS (M + 1) 172.2; 1H NMR (400 MHz, CD2Cl2) δ 2.89 (ddd, J = 12.9, 8.7, 3.3 Hz, 2H), 2.75 (ddd, J = 12.9, 6.6, 3.7 Hz, 2H), 2.45 (q, J = 7.2 Hz, 2H), 1.95 ( ddd, J = 13.7, 8.3, 3.7 Hz, 2H), 1.55 (ddd, J = 13.7, 6.6, 3.3 Hz, 2H), 1.08 (t, J = 7.2 Hz, 3H). | | References | [1] Patent: WO2004/37823, 2004, A1. Location in patent: Page 71-72
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 2, p. 234 - 237
[3] Patent: US2004/157838, 2004, A1. Location in patent: Page 26
[4] Patent: US2004/157839, 2004, A1. Location in patent: Page 26
[5] Patent: US2004/259887, 2004, A1. Location in patent: Page 21 |
| | 4-(ethylamino)piperidine-4-carboxamide Preparation Products And Raw materials |
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