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hydromorphinol

hydromorphinol Basic information
Product Name:hydromorphinol
Synonyms:14-Hydroxydihydromorphine;Oxymorphol;6-Alpha-Hydroxy OxyMorphone;(5α,6α)-4,5-Epoxy-17-MethylMorphinan-3,6,14-triol;AABLHGPVOULICI-BRJGLHKUSA-N;6-Oxymorphol (CRM);hydromorphinol;(5a,6a)-4,5-Epoxy-17-methylmorphinan-3,6,14-triol
CAS:2183-56-4
MF:C17H21NO4
MW:303.36
EINECS:218-565-9
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:2183-56-4.mol
hydromorphinol Structure
hydromorphinol Chemical Properties
Melting point 252-253 °C(Solv: ethyl acetate (141-78-6))
Boiling point 517.6±50.0 °C(Predicted)
density 1.50±0.1 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml
form A neat solid
pka9.39±0.60(Predicted)
Safety Information
DEA Controlled SubstancesCSCN: 9301
CSA SCH: Schedule I
NARC: Yes
MSDS Information
hydromorphinol Usage And Synthesis
Description6α-Oxymorphol (CRM) (Item No. 25940) is a certified reference material categorized as an opioid. It is a metabolite of oxymorphone (Item Nos. 15911 | ISO60171). 6α-Oxymorphol is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.
UsesA metabolite of Oxymorphone
Brand nameIfex (Bristol-Myers Squibb).
References[1] RICHARD D.S. CARLISS . Receptor reserve reflects differential intrinsic efficacy associated with opioid diastereomers[J]. Pharmacology Biochemistry and Behavior, 2009, 92 3: Pages 495-502. DOI: 10.1016/j.pbb.2009.01.019
[2] BOJAN LALOVIC PHD  Evan K M, PHD. Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites[J]. Clinical Pharmacology & Therapeutics, 2006, 79 5: 461-479. DOI: 10.1016/j.clpt.2006.01.009
hydromorphinol Preparation Products And Raw materials
Raw materials14-Hydroxydihydrocodeine-->7,8-Dihydro-14-hydroxy- normorphinone-->14-HYDROXYCODEINE-->OXYMORPHONE-->Formaldehyde
Tag:hydromorphinol(2183-56-4) Related Product Information
hydromorphinol nalbuphine 17-[CYCLOBUTYLMETHYL]-4,5-EPOXYMORPHINAN-3,6,14-TRIOL HYDROCHLORIDE, DIHYDRATE NALBUPHINE HYDROCHLORIDE BUPRENORPHINE HYDROCHLORIDE MORPHINE-D3