UMB298 manufacturers
- UMB298
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- $60.00
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2026-08-08
- CAS:2266569-73-5
- Purity: 99.83%
- Supply Ability: 10g
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| Product Name: | UMB298 | | Synonyms: | UMB298;UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30;Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)-;2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine;UMB298, 10 mM in DMSO;2-(3-Chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine | | CAS: | 2266569-73-5 | | MF: | C27H31ClN4O2 | | MW: | 479.01 | | EINECS: | | | Product Categories: | | | Mol File: | 2266569-73-5.mol |  |
| | UMB298 Chemical Properties |
| density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (52.19 mM; Need ultrasonic) | | pka | 7.87±0.50(Predicted) | | form | Solid | | color | White to light yellow |
| | UMB298 Usage And Synthesis |
| Uses | UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. | | Biological Activity | UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].
UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1]. | | IC 50 | BRD4: 5193 nM (IC50) | | References | [1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801. |
| | UMB298 Preparation Products And Raw materials |
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