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| | Azaphilone-9 Basic information |
| Product Name: | Azaphilone-9 | | Synonyms: | Azaphilone-9;6H-2-Benzopyran-6,8(7H)-dione, 7-(acetyloxy)-5-bromo-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl- | | CAS: | 1448460-87-4 | | MF: | C21H23BrO5 | | MW: | 435.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1448460-87-4.mol |  |
| | Azaphilone-9 Chemical Properties |
| Boiling point | 498.0±45.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) |
| | Azaphilone-9 Usage And Synthesis |
| Uses | Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression[1]. | | References | [1] Kaur K, et al. The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. PLoS One. 2017 Apr 17;12(4):e0175471. DOI:10.1371/journal.pone.0175471 |
| | Azaphilone-9 Preparation Products And Raw materials |
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