(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide

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(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide Basic information
Product Name:(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide
Synonyms:(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide;2-Furancarboxamide, N-[3-[(3-fluorophenyl)methyl]-1H-1,2,4-triazol-5-yl]tetrahydro-, (2S)-;GWP-042
CAS:1645486-93-6
MF:C14H15FN4O2
MW:290.29
EINECS:
Product Categories:
Mol File:1645486-93-6.mol
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide Structure
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide Chemical Properties
density 1.404±0.06 g/cm3(Predicted)
storage temp. Storage temp. -20°C
form Solid
pka9.29±0.40(Predicted)
color White to off-white
Safety Information
MSDS Information
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide Usage And Synthesis
UsesGWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo[1].
References[1] Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15(1):4216.c DOI:10.1038/s41467-024-48588-4
(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide Preparation Products And Raw materials
Tag:(S)-N-(5-(3-Fluorobenzyl)-4H-1,2,4-triazol-3-yl)tetrahydrofuran-2-carboxamide(1645486-93-6) Related Product Information
5-[(3-fluorophenyl)methyl]-1H-1,2,4-triazol-3-amine Propanamide, 2-(phenylmethoxy)-N-1H-1,2,4-triazol-5-yl- 5-(4-fluorobenzyl)-1H-1,2,4-triazol-3-amine JHU-083 Q203 RO9021