Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-

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Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- manufacturers

  • IHVR-17028
  • IHVR-17028 pictures
  • $178.00
  • 2026-08-30
  • CAS:1428247-78-2
  • Purity: 99.33%
  • Supply Ability: 10g
Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- Basic information
Product Name:Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-
Synonyms:Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-;IHVR-17028;IHVR-17028, 10 mM in DMSO
CAS:1428247-78-2
MF:C23H44N2O5
MW:428.61
EINECS:
Product Categories:
Mol File:1428247-78-2.mol
Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- Structure
Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- Chemical Properties
Boiling point 617.2±55.0 °C(Predicted)
density 1.15±0.1 g/cm3(Predicted)
pka13.72±0.70(Predicted)
form Oil
color Colorless to light yellow
Safety Information
MSDS Information
Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- Usage And Synthesis
UsesIHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidaseIinhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research[1][2].
in vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a Cmaxvalue of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T1/2 value is 0.88 hour after iv. adminstration[1].IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection[1].

Animal Model:BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
Dosage:50 mg/kg
Administration:Treatment 1 day prior to virus challenging
Result:Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
Animal Model:C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
Dosage:25 mg/kg
Administration:Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result:Inhibited EBOV infection in mice.
References[1] Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40. DOI:10.1016/j.antiviral.2013.03.023
Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]- Preparation Products And Raw materials
Tag:Propanamide, N-cyclohexyl-2,2-dimethyl-N-[6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)-1-piperidinyl]hexyl]-(1428247-78-2) Related Product Information
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