3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl

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3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)- Basic information
Product Name:3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)-
Synonyms:Pan-RAS-IN-7;3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)-
CAS:2642135-72-4
MF:C59H76N8O8
MW:1025.29
EINECS:
Product Categories:
Mol File:2642135-72-4.mol
3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)- Structure
3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)- Chemical Properties
density 1.29±0.1 g/cm3(Predicted)
pka9.71±0.60(Predicted)
Safety Information
MSDS Information
3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)- Usage And Synthesis
UsesPan-RAS-IN-7 (Compound D101) is a pan RAS inhibitor that can be used for the synthesis of ADCs. Pan-RAS-IN-7 can be utilized in cancer research[1].
References[1] Matthew T. B, et al. Panras inhibitor antibody-drug conjugates and methods of use thereof
3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)- Preparation Products And Raw materials
Tag:3-Pyridazinecarboxylic acid, N1-[N-(2,5-anhydro-3,4-dideoxy-3-phenyl-L-threo-pentonoyl)-N-methyl-L-valyl-3-[(2S)-1-ethyl-3-(3-hydroxy-2,2-dimethylpropyl)-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indol-5-yl]-5-hydroxy-L-phenylalanyl]hexahydro-, (3→23)-lactone, (3S)-(2642135-72-4) Related Product Information
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- 2,7-Diazaspiro[4.4]nonane-2-acetamide, α-cyclopentyl-7-[[(2R,3R)-3-cyclopropyl-1-methyl-2-aziridinyl]carbonyl]-N-[(1R,10S,12S,18S)-1-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-2,7,8,10,11,12,13,16,17,18,19,21,22,23-tetradecahydro-22,22-dimethyl-13,19-dioxo-2-(2,2,2-trifluoroethyl)-15H-3,5-etheno-14,18-imino-6,10-methano-6H-pyrrolo[3,4-g][1,12,4,18]dioxadiazacyclodocosin-12-yl]-, (αS,5S)- 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- RMC-7977 EHT1864 RMC5127