2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-

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2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- manufacturers

  • UNC6934
  • UNC6934 pictures
  • $42.00
  • 2026-06-02
  • CAS:2561494-77-5
  • Purity: 99.81%
  • Supply Ability: 10g
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Basic information
Product Name:2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-
Synonyms:2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-;Inhibitor,UNC6934,Histone Methyltransferase,inhibit,UNC 6934,UNC-6934;N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide;UNC6934, 10 mM in DMSO;N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide;UNC6934 ，E1059
CAS:2561494-77-5
MF:C24H21N5O4
MW:443.46
EINECS:
Product Categories:
Mol File:2561494-77-5.mol
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Structure
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Chemical Properties
Boiling point 697.2±55.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
pka10.91±0.70(Predicted)
color Pale yellow
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKeyKOZGEDUWAQFVAV-UHFFFAOYSA-N
SMILESO=C(C1=CC=C(CN(C2CC2)C(C3=CC4=C(NC(CO4)=O)C=C3)=O)C=C1)NC5=CC=NC=N5
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Usage And Synthesis
DescriptionUNC6934 (2561494-77-5) is a potent (IC50 = 104 nM) and selective inhibitor of protein lysine methyltransferase nuclear receptor-binding SET domain-containing 2 (NSD2). It potently binds to the PWWP1 domain antagonizing interaction with nucleosomal H3K36me2. UNC6934 is selective against 14 other human PWWP domains and 33 methyltransferases. Active in a nanoBRET PPI assay in U2OS cells (IC50 = 1.23 μM).
UsesUNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization.
storageStore at -20°C
References[1] DAVID DILWORTH. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization[J]. Nature chemical biology, 2021, 18 1: 56-63. DOI:10.1038/s41589-021-00898-0
2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- Preparation Products And Raw materials
Tag:2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-(2561494-77-5) Related Product Information
PF-01367338 RESINIFERATOXIN DO264 ML335 2H-1,4-Benzoxazine-7-carboxamide, N-cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- NA