4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine

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4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine Basic information
Product Name:4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine
Synonyms:4-(2-(PYRROLIDIN-1-YL)ETHOXY)ANILINE;BenzenaMine, 4-[2-(1-pyrrolidinyl)ethoxy]-;4-(2-Pyrrolidinoethoxy)aniline;4-(2-(Pyrrolidin-1-yl);4-[2-(1-PyrroL;)ethoxy]aniL;4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine
CAS:50609-01-3
MF:C12H18N2O
MW:206.28
EINECS:
Product Categories:
Mol File:50609-01-3.mol
4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine Structure
4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine Chemical Properties
Boiling point 362.2±22.0 °C(Predicted)
density 1.097±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka9.76±0.20(Predicted)
AppearanceLight brown to brown Oil
InChIInChI=1S/C12H18N2O/c13-11-3-5-12(6-4-11)15-10-9-14-7-1-2-8-14/h3-6H,1-2,7-10,13H2
InChIKeyOTYZNDKWNPQQJP-UHFFFAOYSA-N
SMILESC1(N)=CC=C(OCCN2CCCC2)C=C1
Safety Information
HazardClass IRRITANT
HS Code 2921410090
MSDS Information
4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine Usage And Synthesis
Synthesis
4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene

265654-77-1

4-(2-PYRROLIDIN-1-YL-ETHOXY)-PHENYLAMINE

50609-01-3

General procedure for the synthesis of 4-[2-(pyrrolidin-1-yl)ethoxy]aniline from 1-(2-(4-nitrophenoxy)ethyl)pyrrolidine: 1-[2-(4-nitrophenoxy)ethyl]pyrrolidine (purchased from CombiBlocks, LLC, 5.00 g, 0.0212 mol) was dissolved in 100 mL of methanol and 0.5 g of 10% Pd/C catalyst, and the hydrogenation reaction was carried out under a hydrogen atmosphere (using a balloon to provide hydrogen pressure) and the reaction continued overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness, the resulting product was used directly in the next step of the reaction without further purification (Yield: 4.36 g, Yield: 99.88%). Spectral analysis of the product showed LCMS (M + H) 207.4.

References[1] Patent: WO2009/64835, 2009, A1. Location in patent: Page/Page column 168
[2] Patent: WO2004/26823, 2004, A1. Location in patent: Page 36
[3] Patent: WO2016/34642, 2016, A1. Location in patent: Page/Page column 35
[4] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0155; 0157
[5] Journal of Organic Chemistry, 1951, vol. 16, p. 1421,1424
4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine Preparation Products And Raw materials
Raw materials4-(2-Pyrrolidin-1-ylethoxy)nitrobenzene-->1-(2-Chloroethyl)pyrrolidine Hydrochloride-->4-Aminophenol-->Methanol-->Hydrogen
Tag:4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine(50609-01-3) Related Product Information
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