|
|
| | 4-Amino-3,5-dimethyl-benzoic acid methyl ester Basic information |
| Product Name: | 4-Amino-3,5-dimethyl-benzoic acid methyl ester | | Synonyms: | Benzoic acid, 4-aMino-3,5-diMethyl-, Methyl ester;Benzoic acid, 4-amino-3,5-dimethyl-, methyl ester (7CI, 8CI, 9CI, ACI);4-amino-3,5-dimethyl-Benzoic acid methyl ester (7CI 8CI 9CI ACI);Methyl 4-aMino-3,5-diMethylbenzoate;4-Amino-3,5-dimethyl-benzoic acid methyl ester | | CAS: | 3095-48-5 | | MF: | C10H13NO2 | | MW: | 179.22 | | EINECS: | | | Product Categories: | | | Mol File: | 3095-48-5.mol |  |
| | 4-Amino-3,5-dimethyl-benzoic acid methyl ester Chemical Properties |
| Melting point | 106-107℃ | | Boiling point | 331.3±37.0 °C(Predicted) | | density | 1.105±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 2.17±0.10(Predicted) | | Appearance | Light yellow to brown Solid |
| | 4-Amino-3,5-dimethyl-benzoic acid methyl ester Usage And Synthesis |
| Synthesis | Scheme 5, Step B. To a solution of methyl 3,5-dimethyl-4-nitrobenzoate (10.0 g, 0.0478 mol) in methanol (100 mL) at 0°C was sequentially added iron powder (15.7 g, 0.2869 mol) and 37% hydrochloric acid (1.72 g, 0.0478 mol). The reaction mixture was heated to 80 °C and kept for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through a Celite TM bed and the filter cake was washed with methanol. The filtrate was concentrated to dryness to afford methyl 4-amino-3,5-dimethylbenzoate as an unpurified solid (7.8 g, 99% yield). Mass spectrum (m/z): 180.2 (M + 1). | | References | [1] Patent: US6342610, 2002, B2. Location in patent: Page column 125
[2] Patent: WO2014/4230, 2014, A1. Location in patent: Sheet 18; 19
[3] Patent: WO2015/94912, 2015, A1. Location in patent: Page/Page column 10
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 105 - 109 |
| | 4-Amino-3,5-dimethyl-benzoic acid methyl ester Preparation Products And Raw materials |
|