1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]-

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1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- manufacturers

  • CCF0058981
  • CCF0058981 pictures
  • $56.00
  • 2026-08-01
  • CAS:2708934-53-4
  • Purity: 98.94%
  • Supply Ability: 10g
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- Basic information
Product Name:1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]-
Synonyms:1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]-;N-(4-(1H-Imidazol-5-yl)phenyl)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-N-(3-chlorobenzyl)acetamide;CCF981;2-(1H-1,2,3-benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]acetamide;CCF0058981, 10 mM in DMSO
CAS:2708934-53-4
MF:C24H19ClN6O
MW:442.9
EINECS:
Product Categories:
Mol File:2708934-53-4.mol
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- Structure
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- Chemical Properties
Boiling point 752.0±60.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka13.34±0.10(Predicted)
form Solid
color Light brown to brown
Safety Information
MSDS Information
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- Usage And Synthesis
DescriptionCCF0058981, also known as CCF981, is a ML300-Derived, Noncovalent Inhibitor Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV2 3CLpro). CCF0058981 demonstrates nanomolar activity in these respective assays, comparable in potency to remdesivir.
UsesCCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].
References[1] Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro). J Med Chem. 2021 Aug 4;acs.jmedchem.1c00598. DOI:10.1021/acs.jmedchem.1c00598
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- Preparation Products And Raw materials
Tag:1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]-(2708934-53-4) Related Product Information
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- CCF0058981 Brequinar SARS-CoV-2 3CLpro/3C-like protease protein SARS-COV-2 S protein RBD (194A.A, HEK293, HIS) SARS-COV-2 S protein RBD (HEK293, FC)