3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl-

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3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- manufacturers

  • VUF11211
  • VUF11211 pictures
  • $1980.00
  • 2026-07-27
  • CAS:906556-51-2
  • Purity:
  • Supply Ability: 10g
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- Basic information
Product Name:3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl-
Synonyms:3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl-;VUF 11211;VUF11211;VUF-11211
CAS:906556-51-2
MF:C26H35Cl2N5O
MW:504.49
EINECS:
Product Categories:
Mol File:906556-51-2.mol
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- Structure
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- Chemical Properties
Boiling point 621.4±55.0 °C(Predicted)
density 1.219±0.06 g/cm3(Predicted)
pka13.60±0.46(Predicted)
Safety Information
MSDS Information
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- Usage And Synthesis
DescriptionVUF11211 is a potent CXCR3 antagonist. It acts by extending from the minor pocket into the major pocket of the transmembrane domains and binding between residues in helices 1 (Y1.39), 2 (W2.60), 3 (F3.32), 4 (D4.60), 6 (Y6.51), and 7 (S7.39, Y7.43).
UsesVUF11211 is an allosteric inverse CXCR3 agonist with a Kd of 0.65 nM[1].
References[1] Scholten DJ, et al. Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3. Mol Pharmacol. 2015 Apr;87(4):639-48. DOI:10.1124/mol.114.095265
3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl- Preparation Products And Raw materials
Tag:3-Pyridinecarboxamide, 5-chloro-6-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-N-ethyl-(906556-51-2) Related Product Information
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