1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)-

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1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- Basic information
Product Name:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)-
Synonyms:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)-;UGT1A1-IN-1
CAS:2097024-37-6
MF:C22H19NO3
MW:345.39
EINECS:
Product Categories:
Mol File:2097024-37-6.mol
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- Structure
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- Chemical Properties
Boiling point 533.0±38.0 °C(Predicted)
density 1.274±0.06 g/cm3(Predicted)
form Solid
pka9.34±0.15(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- Usage And Synthesis
UsesUGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on UGT1A1 at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1[1].
References[1] Lv X, et al. A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin. J Med Chem. 2017 Dec 14;60(23):9664-9675. DOI:10.1021/acs.jmedchem.7b01097
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)- Preparation Products And Raw materials
Tag:1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-butyl-6-(4-hydroxyphenyl)-(2097024-37-6) Related Product Information
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