| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Oxaprozin potassium
CAS:174064-08-5
Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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Oxaprozin, potassium salt manufacturers
- Oxaprozin potassium
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- $1520.00 / 25mg
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2025-05-01
- CAS:174064-08-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Oxaprozin, potassium salt Basic information |
| | Oxaprozin, potassium salt Chemical Properties |
| | Oxaprozin, potassium salt Usage And Synthesis |
| Uses | Oxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2]. | | IC 50 | COX-1: 2.2 μM (IC50); COX-2: 36 μM (IC50); NF-κB; IKK | | References | [1] Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306. DOI:10.1111/j.1476-5381.2009.00162.x
[2] Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785. DOI:10.1155/2009/478785 |
| | Oxaprozin, potassium salt Preparation Products And Raw materials |
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