Oxaprozin potassium NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Oxaprozin potassium | CAS No.: 174064-08-5 |
| Supply Ability: 10g | Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Oxaprozin potassium |
| Description | Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. It induces cell apoptosis and inhibits NF-κB activation. The inhibition of the Akt/IKK/NF-κB pathway by oxaprozin potassium contributes to its anti-inflammatory properties [1] [2]. |
| In vitro | Oxaprozin, across a concentration range of 0-100 μM, triggers apoptosis in a dose-dependent manner, with its most potent proapoptotic effect observed at 100 μM. This compound specifically elevates caspase-3 activity under activated conditions, while not affecting it in resting states. At a concentration of 50 μM, Oxaprozin effectively suppresses NF-κB activation and blocks the induction of the IKK system by IκBα. Furthermore, Oxaprozin significantly enhances apoptosis in CD40L-treated monocytes and abrogates CD40L-induced Akt and NF-κB (p65) phosphorylation, underscoring its potential in modulating inflammatory and apoptotic pathways. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $48.00/50mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-09-29 | |
| $48.00/50mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-09-29 | |
| $0.00/25Kg/Drum |
VIP7Y
|
Jinan Finer Chemical Co., Ltd
|
2021-12-13 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY