Flesinoxan manufacturers
- Flesinoxan HCl
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- $1970.00
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2026-05-11
- CAS:98205-89-1
- Purity:
- Supply Ability: 10g
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| | Flesinoxan Basic information |
| Product Name: | Flesinoxan | | Synonyms: | Benzamide, N-(2-(4-((2R)-2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluoro-, monohydrochloride;Benzamide, N-(2-(4-(2,3-dihydro-2-(hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)ethyl)-4-fluoro-, monohydrochloride;Flesinoxan HCl;4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide | | CAS: | 98205-89-1 | | MF: | C22H26FN3O4.ClH | | MW: | 451.92 | | EINECS: | | | Product Categories: | | | Mol File: | 98205-89-1.mol |  |
| | Flesinoxan Chemical Properties |
| Melting point | 184.5-185.5°; mp 183.0-184.0° (Ennis) | | alpha | D +25° (c = 1 in methanol) |
| | Flesinoxan Usage And Synthesis |
| Uses | Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects[1][2][3]. | | References | [1] Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34(10):1311-26. DOI:10.1016/0028-3908(95)00098-q
[2] Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. DOI:10.1111/j.1476-5381.1988.tb11728.x
[3] Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48(4):959-63. DOI:10.1016/0091-3057(94)90205-4 |
| | Flesinoxan Preparation Products And Raw materials |
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