| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:GABAA receptor agent 4
CAS:2035203-91-7
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
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Methanone, 3,9-diazaspiro[5.5]undec-3-yl(3-methylphenyl)- manufacturers
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| | Methanone, 3,9-diazaspiro[5.5]undec-3-yl(3-methylphenyl)- Basic information |
| | Methanone, 3,9-diazaspiro[5.5]undec-3-yl(3-methylphenyl)- Chemical Properties |
| Boiling point | 448.7±45.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | pka | 10.94±0.20(Predicted) |
| | Methanone, 3,9-diazaspiro[5.5]undec-3-yl(3-methylphenyl)- Usage And Synthesis |
| Uses | GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 μM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential[1]. | | References | [1] Bavo F,et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64(24):17795-17812. DOI:10.1021/acs.jmedchem.1c00290 |
| | Methanone, 3,9-diazaspiro[5.5]undec-3-yl(3-methylphenyl)- Preparation Products And Raw materials |
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