人牛吡啶APELIN-13
| 中文名称 | 人牛吡啶APELIN-13 |
|---|---|
| 中文同义词 | 人牛吡啶APELIN-13;人,牛(GLP1)-APELIN-13肽;[PYR1]-爱帕琳肽-13, >98%;[PYR1]-爱帕琳肽-13;(S)-2-((S)-1-((S)-2-((S)-1-((6S,9S,12S,15S,18S)-15-((1H-咪唑-4-基)甲基)-1-氨基-18-(4-氨基丁基)-6-((S)-1-((S)-5-胍基-2-((S)-5-氧代吡咯烷-2-甲酰氨基)戊酰基)吡咯烷-2-甲酰氨基)-12-(羟甲基)-1-亚氨基-9-异丁基7,10,13,16,19-五氧代-2,8,11,14,17,20-六氮杂二十二烷-22-酰基)吡咯烷-2-甲酰氨基)-4-(甲硫基)丁酰基)吡咯烷-2-甲酰氨基)-3-苯基丙酸;3-二甲基尿酸;PYR1] -APELIN-13 三氟乙酸盐;PYR1]-爱帕琳肽-13醋酸盐 |
| 英文名称 | Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
| 英文同义词 | (GLP1)-APELIN-13, HUMAN, BOVINE;GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE;(Glp1)-Apelin-13;5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine;Pyr-apelin-13;GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE: GRPRLSHKGPMPF;[PE]APELIN-13, HUMAN, BOVINE;PYR-RPRLSHKGPMPF-OH |
| CAS号 | 217082-60-5 |
| 分子式 | C69H108N22O16S |
| 分子量 | 1533.8 |
| EINECS号 | |
| 相关类别 | 多肽;目录多肽;peptide |
| Mol文件 | 217082-60-5.mol |
| 结构式 |  |
人牛吡啶APELIN-13 性质
| 密度 | 1.51±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.56±0.10(Predicted) |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 1 mg/ml in sterile water |
| 序列 | Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
| InChIKey | GGMAXEWLXWJGSF-PEWBXTNBSA-N |
[Pyr1]-Apelin-13 是一种高效的，选择性的内源性 apelin 受体激动剂。
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions.
[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.
参考质量标准
外观:白色粉末纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-P1033 | 人牛吡啶APELIN-13 [Pyr1]-Apelin-13 | 217082-60-5 | 1mg | 784元 |
| 2026/09/15 | HY-P1033 | 人牛吡啶APELIN-13 [Pyr1]-Apelin-13 | 217082-60-5 | 2 mg | 1254元 |