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| | DIBAC-GGFG-NH2CH2-Dxd Basic information |
| | DIBAC-GGFG-NH2CH2-Dxd Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | pka | 11.18±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | DIBAC-GGFG-NH2CH2-Dxd Usage And Synthesis |
| Uses | DIBAC-GGFG-NH2CH2-Dxd (compound LP4), a Camptothecin (HY-16560) derivative, is a linker-payload of protein-agent conjugates[1]. Dxd (HY-13631D) can be used as a payload for the antibody-coupling drug ADC (DS-8201a).DIBAC-GGFG-NH2CH2-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1][2]. | | References | [1] Amy Han, et al. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656A1
[2] Protein-drug conjugates comprising camptothecin analogs and methods of use thereof |
| | DIBAC-GGFG-NH2CH2-Dxd Preparation Products And Raw materials |
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Tag:DIBAC-GGFG-NH2CH2-Dxd(2758875-01-1)
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