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| | Chimaphilin Basic information |
| Product Name: | Chimaphilin | | Synonyms: | 2,7-Dimethyl-1,4-naphthalenedione;2,7-dimethylnaphthalene-1,4-dione;7-Dimethyl-1;1,4-Naphthalenedione, 2,7-dimethyl- | | CAS: | 482-70-2 | | MF: | C12H10O2 | | MW: | 186.21 | | EINECS: | | | Product Categories: | | | Mol File: | 482-70-2.mol |  |
| | Chimaphilin Chemical Properties |
| Melting point | 113.5-114.5°; mp 232-233° | | Boiling point | 346.8±42.0 °C(Predicted) | | density | 1.187 |
| | Chimaphilin Usage And Synthesis |
| Uses | Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2]. | | Definition | ChEBI: Chimaphylin is a member of 1,4-naphthoquinones. | | References | [1] Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. DOI:10.1016/j.cbi.2015.05.008
[2] Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8. DOI:10.1016/j.fct.2014.04.014 |
| | Chimaphilin Preparation Products And Raw materials |
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