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| | Clanfenur Basic information |
| Product Name: | Clanfenur | | Synonyms: | Clanfenur;Benzamide,N-[[(4-chlorophenyl)amino]carbonyl]-2-(dimethylamino)-6-fluoro-;N-[[(4-chlorophenyl)amino]carbonyl]-2-(dimethylamino)-6-fluorobenzamide;N-((4-Chlorophenyl)carbamoyl)-2-(dimethylamino)-6-fluorobenzamide;3-(4-chlorophenyl)-1-[2-(dimethylamino)-6-fluorobenzoyl]urea;Clanfenur, 10 mM in DMSO | | CAS: | 51213-99-1 | | MF: | C16H15ClFN3O2 | | MW: | 335.76 | | EINECS: | | | Product Categories: | | | Mol File: | 51213-99-1.mol |  |
| | Clanfenur Chemical Properties |
| density | 1.371±0.06 g/cm3(Predicted) | | solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/mL
DMSO: Sparingly soluble: 1-10 mg/mL | | form | Solid | | pka | 9.37±0.46(Predicted) | | color | White to off-white |
| | Clanfenur Usage And Synthesis |
| Uses | Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1]. | | References | [1] J D Jonkman-de Vries, et al. Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51(2):89-95. PMID:9146040
[2] H P HOFS J G M. Effects of benzoylphenyl ureas on growth of B16 melanoma cells in vitro and in vivo.[J]. Investigational New Drugs, 1991, 9 3: 227-232. DOI: 10.1007/bf00176975
[3] V K JENKINS. Effects of diflubenzuron and clanfenur on mouse bone marrow cells.[J]. Investigational New Drugs, 1993, 11 4: 279-289. DOI: 10.1007/bf00874426 |
| | Clanfenur Preparation Products And Raw materials |
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