Kelatorphan manufacturers
- Kelatorphan
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- $1820.00
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2026-07-27
- CAS:92175-57-0
- Purity:
- Supply Ability: 10g
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| | Kelatorphan Basic information |
| Product Name: | Kelatorphan | | Synonyms: | Kelatorphan;N-[(R)-4-(Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-alanine;OJCFZTVYDSKXNM-GXSJLCMTSA-N;(2S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]propanoic acid;L-Alanine, N-[(2R)-4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]- | | CAS: | 92175-57-0 | | MF: | C14H18N2O5 | | MW: | 294.3 | | EINECS: | | | Product Categories: | | | Mol File: | 92175-57-0.mol |  |
| | Kelatorphan Chemical Properties |
| density | 1.301±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 3.58±0.10(Predicted) | | color | White to off-white |
| | Kelatorphan Usage And Synthesis |
| Uses | Kelatorphan is a full inhibitor of enkephalin degrading enzymes. | | in vivo | The administration of Kelatorphan alone (50 μg) could result in a strong increase of intact [3H]enkephalin content corresponding to 80±11% of total recovered radioactivity[2]. In normal awake rats, Kelatorphan (10±20 mg/kg i.v.) increases minute-volume. The increase in ventilation is due to a dose-dependent increase in breathing frequency. In arthritic rats Kelatorphan (20 mg/kg i.v.) increases ventilation and there is no significant difference between arthritic and non-arthritic rats. In pentobarbital-anesthetized rats, a slight (116%) but significant increase of respiration is also produced by Kelatorphan (20 mg/kg, n=6) 10±15 min after administration. The effects of Kelatorphan are not antagonized by a pretreatment with a small dose of naloxone (0.2 mg/kg i.v., 15 min before Kelatorphan), but a larger dose (1 mg/kg) significantly antagonized Kelatorphan (20 mg/kg) at 5 and 10 min in awake rats[3]. | | References | [1] Waksman G, et al. Kelatorphan: a full inhibitor of enkephalin degrading enzymes. Biochemical and pharmacological properties, regional distribution of enkephalinase in rat brain by use of a tritiated derivative. Neuropeptides. 1985 Feb;5(4-6):529-32. DOI:10.1016/0143-4179(85)90071-x
[2] Waksman G, et al. In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain. Eur J Pharmacol. 1985 Nov 5;117(2):233-43.
[3] Boudinot E, et al. Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration. Pain. 2001 Feb 1;90(1-2):7-13. DOI:10.1016/s0304-3959(00)00382-1 |
| | Kelatorphan Preparation Products And Raw materials |
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