2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-

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2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Basic information
Product Name:2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-
Synonyms:2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-;KRAS G12C inhibitor 37
CAS:2241720-04-5
MF:C35H39F3N8O2
MW:660.73
EINECS:
Product Categories:
Mol File:2241720-04-5.mol
2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Structure
2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Chemical Properties
Boiling point 823.2±75.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
pka12.29±0.40(Predicted)
Safety Information
MSDS Information
2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Usage And Synthesis
UsesKRAS G12C inhibitor 37 is a potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12C inhibitor 37 has the potential for the research of KRAS G12C-mediated cancer (extracted from patent WO2018143315A1, compound 65)[1].
References[1] Quinazoline compound. Patent WO2018143315A1.
2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]- Preparation Products And Raw materials
Tag:2-Propen-1-one, 1-[7-[2-[3-(dimethylamino)-1-azetidinyl]-6-ethenyl-7-(5-methyl-1H-indazol-4-yl)-8-(2,2,2-trifluoroethoxy)-4-quinazolinyl]-2,7-diazaspiro[3.5]non-2-yl]-(2241720-04-5) Related Product Information
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