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| | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Basic information |
| Product Name: | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate | | Synonyms: | 4-(2-Fluoro-4-nitrophenyl)piperazine, N1-BOC protected;tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate;1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine, 97%;3-Fluoro-4-[4-(tert-butoxycarbonyl)piperazin-1-yl]nitrobenzene;1-Piperazinecarboxylic acid, 4-(2-fluoro-4-nitrophenyl)-, 1,1-dimethylethyl ester;1-Boc-4-(2-Fluoro-4-nitrophenyl)piperazine,97%;1-boc-4-(2-fluoro-4-nitrophenyl)piperazine | | CAS: | 154590-34-8 | | MF: | C15H20FN3O4 | | MW: | 325.34 | | EINECS: | | | Product Categories: | | | Mol File: | 154590-34-8.mol |  |
| | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Chemical Properties |
| Melting point | 153-155 °C(Solv: ethyl ether (60-29-7)) | | Boiling point | 453.5±45.0 °C(Predicted) | | density | 1.270±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | Solid | | pka | 0.11±0.10(Predicted) | | Appearance | Light yellow to yellow Solid | | CAS DataBase Reference | 154590-34-8 |
| | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Usage And Synthesis |
| Synthesis | General procedure for the synthesis of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate:
1. 1-(2-fluoro-4-nitrophenyl)piperazine (12.5 g, 55.8 mmol) was dissolved in 1,4-dioxane (108 mL) under cooling conditions in an ice bath.
2. 1N sodium hydroxide solution (54 mL) and di-tert-butyl dicarbonate (14 mL, 61.38 mmol) were added sequentially to the above solution.
3. The temperature of the reaction mixture was adjusted to 25-35°C and stirred continuously for 0.5 hours.
4. Upon completion of the reaction, the mixture was poured into ice-cold water (200 mL) and a yellow precipitate was precipitated.
5. The precipitate was collected by filtration through a Büchner funnel to afford the target product tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (18.0 g, 99% yield).
Product characterization data:
1H NMR (CDCl3): δ 8.01-7.88 (m, 2H), 6.93 (t, J = 8.6 Hz, 1H), 3.61 (t, J = 4.9 Hz, 4H), 3.24 (t, J = 4.9 Hz, 4H), 1.49 (s, 9H).
IR (KBr, cm-1): 3119, 1692, 1605, 1512.
CI-MS (m/z): 326 (M++1), 270, 240, 226, 195, 183, 131, 96. | | References | [1] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 61
[2] Patent: CN107033095, 2017, A. Location in patent: Paragraph 0085; 0086
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 19, p. 4261 - 4267
[4] Patent: US2004/220194, 2004, A1. Location in patent: Page 13; 14
[5] Patent: US2005/239795, 2005, A1. Location in patent: Page/Page column 18 |
| | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate Preparation Products And Raw materials |
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