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| | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol Basic information |
| Product Name: | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol | | Synonyms: | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol;4-[4-(2-Hydroxyethyl)piperazin-1-yl]aniline;2-(4-(4-Aminophenyl);AKOS BB1150;OTAVA-BB 7020694390;VITAS-BB TBB005536;4-[4-(2-Hydroxyethyl)piperazin-1-yl]aniline 97%;1-Piperazineethanol, 4-(4-aminophenyl)- | | CAS: | 5521-39-1 | | MF: | C12H19N3O | | MW: | 221.3 | | EINECS: | | | Product Categories: | | | Mol File: | 5521-39-1.mol | ![2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol Structure](CAS/GIF/5521-39-1.gif) |
| | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol Chemical Properties |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | Appearance | Brown to black Solid |
| HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol Usage And Synthesis |
| Synthesis | 2-[4-(4-nitrophenyl)piperazin-1-yl]ethanol (3.6 g, 14.3 mmol) was used as a starting material and dissolved in methanol (40 mL). To this solution was added palladium/carbon catalyst (700 mg) and the reaction mixture was stirred at 0 °C overnight. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 2-[4-(4-aminophenyl)piperazin-1-yl]ethanol (2.8 g, 88% yield) as a yellow solid. | | References | [1] Patent: WO2015/27222, 2015, A2. Location in patent: Paragraph 0323
[2] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 113
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
[4] Patent: US2004/87575, 2004, A1
[5] Patent: US2003/13708, 2003, A1 |
| | 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol Preparation Products And Raw materials |
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