Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-

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Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- manufacturers

  • TGFβ1-IN-1
  • TGFβ1-IN-1 pictures
  • $92.00
  • 2025-12-22
  • CAS:2348795-14-0
  • Purity: 99.89%
  • Supply Ability: 10g
Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- Basic information
Product Name:Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-
Synonyms:Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-;N-Cyclopentyl-3-(3-(4-methoxyphenyl)acrylamido)benzamide
CAS:2348795-14-0
MF:C22H24N2O3
MW:364.44
EINECS:
Product Categories:
Mol File:2348795-14-0.mol
Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- Structure
Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- Chemical Properties
Boiling point 636.1±55.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
pka13.47±0.70(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- Usage And Synthesis
UsesTGFβ1-IN-1 (compound 42) is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies[1].
in vivo

TGFβ1-IN-1 (compound 42) (p.o., 15 or 30 mg/kg, daily, 3weeks) prevents CCl4-induced liver injury and fibrosis, inhibits the activation of hepatic stellate cell (HSC) and epithelial-mesenchymal transition (EMT), and improves the immune microenvironment of CCl4-induced liver fibrosis as well as CCl4-induced systemic toxicity in C57BL/6J mice[1].

Animal Model:Liver fibrosis C57BL/6J mice induced by CCl4[1]
Dosage:15 or 30 mg/kg
Administration:Oral administration; daily; 3 weeks
Result:Significantly prevented CCl4-induced liver injury and reduced liver weight factor, serum ALT, AST, CHO and TG levels.
Significantly improved structural damage and inflammatory cell infiltration in the liver, and reduced collagen deposition in liver tissue.
Reduced accumulation of CCl4-induced immune cells, such as hepatic macrophages (F4/80+ CD11b+), Th1 cells (CD69+ CD4+), and Th2 cells (CD69+ CD8+) so on.
References[1] Lin Yue, et al. Discovery and evaluation of phenacrylanilide derivatives as novel potential anti-liver fibrosis agents. Eur J Med Chem. 2022 Nov 15;242:114685. DOI:10.1016/j.ejmech.2022.114685
Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]- Preparation Products And Raw materials
Tag:Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-(2348795-14-0) Related Product Information
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